The Sinister Six was formed when Doctor Octopus captured Curt Connors and lured Spider-Man to his underwater lab, hiring the Rhino, Kraven the Hunter, the Beetle and Electro. When Spider-Man arrived, they attacked him and Doc Ock transformed Connors back into the Lizard, all six attacking him alone, attempting to unmask him, but he escaped outside the lab and called his team, where White Tiger, Power Man, Iron Fist and Nova arrived and they
defeated their opponents. Spider-Man got Connors to resist Octavius' control and smashed his control device, then unplugging Otto's four arms with the Lizard knocked out. However, the Lizard soon woke up and escaped into the sewers and Spider-Man tried to save him, but the Lizard said he wouldn't stop failing. The other five members of the Sinister Six were then locked away in S.H.I.E.L.D.'s new headquarters..
- Doctor Octopus/Dr. Otto Octavius (Leader)
- Beetle/Abner Jenkins
- Electro/Max Dillon
- Kraven the Hunter/Sergei Karvinoff
- Lizard/Dr. Curt Connors (Unwillingly)
- Rhino/Alexander Sytsevich
Background in other media
- In the comics, the original Sinister Six consisted of Doctor Octopus, Vulture, Electro, Kraven the Hunter, Mysterio and Sandman.