Spider-Man and Triton must stop a war between S.H.I.E.L.D. and the Inhumans.
This episode is depicted to take place after episode Inhuman Nature of Hulk and the Agents of S.M.A.S.H.
When Spider-Man remarks "I used to have a dog named Ms. Lion," this is a reference to Aunt May's, ironically, male dog, Ms. Lion, who, along with Lockjaw, is a member of the Pet Avengers in Marvel comics.
Great Power | Great Responsibility | Doomed! | Venom | Flight of the Iron Spider | Why I Hate Gym | Exclusive | Back In Black | Field Trip | Freaky | Venomous | Me Time | Strange | Awesome | For Your Eye Only | Beetle Mania | Snow Day | Damage | Home Sick Hulk | Run Pig Run | I Am Spider-Man | The Iron Octopus | Not a Toy | The Attack of the Beetle | Revealed | The Rise of the Goblin
The Lizard | Electro | The Rhino | Kraven the Hunter | Hawkeye | The Sinister Six | Spidah-Man! | Carnage | House Arrest | The Man-Wolf | Swarm | Itsy Bitsy Spider-Man | Journey of the Iron Fist | The Incredible Spider-Hulk | Stan By Me | Ultimate Deadpool | Venom Bomb | Guardians of the Galaxy | The Parent Trap | Game Over | Blade | The Howling Commandos | Second Chance Hero | Sandman Returns | Return of the Sinister Six | Ultimate
The Avenging Spider-Man ( Part 1, Part 2) | Agent Venom | Cloak and Dagger | The Next Iron Spider | The Vulture | The Savage Spider-Man | New Warriors | The Spider-Verse ( Part 1, Part 2, Part 3, Part 4) | The Return of the Guardians of the Galaxy | S.H.I.E.L.D. Academy | The Rampaging Rhino | Ant-Man | Burrito Run | Inhumanity | Attack of the Synthezoids | The Revenge of Arnim Zola | Halloween Night at the Museum | Nightmare on Christmas | Contest of Champions ( Part 1, Part 2, Part 3, Part 4)
Hydra Attacks ( Part 1, Part 2) | Miles From Home | Iron Vulture | Lizards | Double Agent Venom | Beached | Anti-Venom | Force of Nature | The New Sinister Six ( Part 1, Part 2) | Agent Web | The Symbiote Saga ( Part 1, Part 2, Part 3) | Return to the Spider-Verse ( Part 1, Part 2, Part 3, Part 4) | Strange Little Halloween | The Spider Slayers ( Part 1, Part 2, Part 3) | The Moon Knight Before Christmas | Graduation Day ( Part 1, Part 2)